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"What's up?" tells the story of six friends aged between 18 and 24. They are all college students. Their names are: Bárbara (Ariela Massoti), Eduardo (Daniel Aguiar), Renata (Andréia Horta), Ricardo (Vergniaud Mendes), Flávia (Lana Rodes) and Caio (Guilherme Boury). The plot starts in Diamantina (Minas Gerais), the city where Bárbara was born. She is sweet, sensible, beautiful and determined. She falls in love with Eduardo and goes to Rio de Janeiro to look for him. But, she feels disappointed because her great love does not remember her. She then meets Ricardo, a university tutor and she will be divided between her two friends. She drops out of med school and goes to Rio de Janeiro to study biology. She decides to do so because she wants to live near Eduardo, a seductive, handsome young surfer who she meets in Diamantina during his vacations. He is irresponsible and all the girls care about him. He can't resist to any woman and this will cause him many problems. Bárbara leaves ...
| Series cast summary: | |||
 | Guilherme Boury | - | Caio 152 episodes, 2006-2007 |
 | Andréia Horta | - | Renata 143 episodes, 2006-2007 |
| Ariela Massotti | - | Bárbara Carvalho 139 episodes, 2006-2007 |
| Vergniaud Mendes | - | Ricardo 131 episodes, 2006-2007 |
| Lana Rhodes | - | Flávia 131 episodes, 2006-2007 |
| Daniel Aguiar | - | Eduardo 119 episodes, 2006-2007 |
| Maurício Ribeiro | - | João Pedro 119 episodes, 2006-2007 |
| Felipe Cardoso | - | Pepeu 110 episodes, 2006-2007 |
| Natallia Rodrigues | - | Taíssa 102 episodes, 2006-2007 |
| Fábio Lago | - | Zen 96 episodes, 2006-2007 |
| João Vitti | - | Gustavo 92 episodes, 2006-2007 |
| Eliete Cigarini | - | Bianca Carvalho 84 episodes, 2006-2007 |
| Cássia Linhares | - | Ana Lúcia 84 episodes, 2006-2007 |
| Roberto Pirillo | - | Olavo Carvalho 84 episodes, 2006-2007 |
| Marina Lopes | - | Mariana 73 episodes, 2006-2007 |
| Cláudia Alencar | - | Lalá 65 episodes, 2006-2007 |
| Larissa Machado | - | Clara 63 episodes, 2006-2007 |