Sherlock Holmes in the 22nd Century The Sign of Four (1999–2001) Online
- Original Title :
- The Sign of Four
- Genre :
- TV Episode / Animation / Action / Adventure / Crime / Mystery / Sci-Fi
- Year :
- 1999–2001
- Directror :
- Robert Brousseau,Scott Heming
- Cast :
- Jason Gray-Stanford,John Payne,Akiko Morison
- Writer :
- Arthur Conan Doyle,Phil Harnage
- Type :
- TV Episode
- Time :
- 22min
- Rating :
- 6.2/10
20 years after her father died during a moon-quake, Mary Morstan is summoned to the moon by the son of her father's business partner. Holmes and Watson are invited along for the ride.
| Episode cast overview, first billed only: | |||
 | Jason Gray-Stanford | - | Sherlock Holmes (voice) |
 | John Payne | - | Dr. John Watson (voice) |
 | Akiko Morison | - | Inspector Beth Lestrade (voice) (credit only) |
 | Viv Leacock | - | Wiggins (voice) (credit only) |
 | Jennifer Copping | - | Deidre (voice) (credit only) |
 | Richard Newman | - | Professor James Moriarty (voice) (credit only) |
 | Ian James Corlett | - | Martin Fenwick (voice) (credit only) |
 | William Samples | - | Chief Inspector Greyson (voice) (credit only) |
 | Jo Bates | - | Newscaster (voice) (credit only) |
 | Sharon Alexander | - | Guest Voice (voice) |
 | Gillian Barber | - | Guest Voice (voice) |
| Kathleen Barr | - | Guest Voice (voice) |
 | Lisa Ann Beley | - | Guest Voice (voice) (as Lisa Anne Beley) |
| Ewan 'Sudsy' Clark | - | Guest Voice (voice) (as Sudsy Clarke) |
| Bernard Cuffling | - | Guest Voice (voice) |