| Series cast summary: |
 | Charlie Brooks | - | Herself / - 9 episodes, 2000-2011 |
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| Perry Fenwick | - | Himself 8 episodes, 2001-2010 |
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 | Shane Richie | - | Himself / - 8 episodes, 2003-2011 |
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 | Pam St. Clement | - | Herself 7 episodes, 2000-2010 |
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| Derek Martin | - | Himself 6 episodes, 2001-2010 |
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| Steve McFadden | - | Himself / - 7 episodes, 2002-2012 |
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 | Barbara Windsor | - | Herself / - 8 episodes, 2002-2010 |
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| Jessie Wallace | - | Herself 6 episodes, 2002-2010 |
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| Adam Woodyatt | - | Himself 5 episodes, 2002-2009 |
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 | Leslie Grantham | - | Himself / - 6 episodes, 2003-2011 |
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| Rita Simons | - | Herself / - 5 episodes, 2009-2011 |
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 | Tracy Ann Oberman | - | Herself / - 4 episodes, 2005-2007 |
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| June Brown | - | Herself / - 4 episodes, 2000-2008 |
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| Kim Medcalf | - | Herself 4 episodes, 2002-2005 |
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 | Gary Beadle | - | Himself 5 episodes, 2002-2010 |
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 | Samantha Womack | - | Herself / - 4 episodes, 2009-2010 |
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| Dean Gaffney | - | Himself 4 episodes, 2002-2010 |
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| Mike Reid | - | Himself 9 episodes, 2000-2011 |
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| Laurie Brett | - | Herself 3 episodes, 2007-2010 |
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 | John Altman | - | Himself 3 episodes, 2008-2010 |
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 | Larry Lamb | - | Himself / - 6 episodes, 2008-2011 |
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 | Leila Birch | - | Herself 2 episodes, 2000-2005 |
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 | Colin Murray | - | Himself - Presenter 2 episodes, 2002-2003 |
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| Michael Greco | - | Himself 2 episodes, 2000-2002 |
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| Tony Caunter | - | Himself 2 episodes, 2000-2001 |
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 | Shaun Williamson | - | Himself / - 3 episodes, 2002-2010 |
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 | Tamzin Outhwaite | - | Herself 3 episodes, 2002-2009 |
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| Natalie Cassidy | - | Herself 2 episodes, 2002-2007 |
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 | Kacey Ainsworth | - | Herself 2 episodes, 2002-2005 |
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| Louise Berridge | - | Herself 2 episodes, 2002-2003 |
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 | Nicholas R. Bailey | - | Himself 2 episodes, 2002 |
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| Alex Ferns | - | Himself 3 episodes, 2002-2008 |
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| Elaine Lordan | - | Herself 2 episodes, 2002 |
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 | Jack Ryder | - | Himself 2 episodes, 2002 |
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 | Richard Shelton | - | Inspector Rossi 2 episodes, 2002 |
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| Letitia Dean | - | Herself 2 episodes, 2003-2005 |
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 | Anita Dobson | - | Herself 2 episodes, 2003-2005 |
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| Diane Parish | - | Herself 2 episodes, 2007-2010 |
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| Charlie Jones | - | Himself 3 episodes, 2007-2010 |
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 | Jo Joyner | - | Herself 2 episodes, 2008-2011 |
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 | Jake Wood | - | Himself 2 episodes, 2008-2011 |
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 | Charlie Clements | - | Himself 2 episodes, 2008-2009 |
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| Scott Maslen | - | Himself 2 episodes, 2008-2009 |
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| Sid Owen | - | Himself 3 episodes, 2008-2010 |
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 | Lacey Turner | - | Herself / - 2 episodes, 2009-2010 |
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| Jayne Middlemiss | - | Herself - Presenter 1 episode, 2000 |
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| Harriet Saxton | - | Herself - Presenter 1 episode, 2001 |
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| Julia Bradbury | - | Herself - Presenter 1 episode, 2002 |
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 | Stephen Tompkinson | - | Himself - Narrator 1 episode, 2002 |
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 | Fearne Cotton | - | Narrator 1 episode, 2004 |
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| Kirsten O'Brien | - | Narrator 1 episode, 2005 |
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| Arthur Smith | - | Narrator 1 episode, 2005 |
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| Angharad Jones | - | Young Pat 1 episode, 2000 |
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 | Simon Paul Sutton | - | Young Frank 1 episode, 2000 |
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| Carly Hillman | - | Herself 1 episode, 2005 |
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| Terry Besson | - | Himself 1 episode, 2000 |
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 | Guy Ritchie | - | Himself 1 episode, 2000 |
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| Christopher Watson | - | Himself 1 episode, 2000 |
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 | Goldie | - | Himself 1 episode, 2001 |
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| Ashvin Luximon | - | Himself 1 episode, 2001 |
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 | Ronni Ancona | - | Herself 1 episode, 2002 |
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| Tony Auger | - | Himself 1 episode, 2002 |
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| Lucy Benjamin | - | Herself 2 episodes, 2002-2010 |
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 | Lionel Blair | - | Himself 1 episode, 2002 |
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| Emma Bridgeman-Williams | - | Herself 1 episode, 2002 |
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 | Kenneth Glenaan | - | Himself 1 episode, 2002 |
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| Tony Jordan | - | Himself 1 episode, 2002 |
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| Oliver Kent | - | Himself 1 episode, 2002 |
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| Laila Morse | - | Herself 1 episode, 2002 |
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| Denise Ryan | - | Herself 1 episode, 2002 |
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 | Matthew Steer | - | Himself 1 episode, 2002 |
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| Claire Wilson | - | Herself 1 episode, 2002 |
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 | Dale Winton | - | Himself 1 episode, 2002 |
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| Richard Blackwood | - | Himself 1 episode, 2003 |
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| Jennie Bond | - | Herself 1 episode, 2003 |
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| Ross Davidson | - | Himself 1 episode, 2003 |
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| Ortis Deley | - | Himself 1 episode, 2003 |
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| Nigel Harman | - | Himself 2 episodes, 2003-2010 |
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| Tony Holland | - | Himself 1 episode, 2003 |
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| Jane How | - | Herself 1 episode, 2003 |
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 | Scarlett Alice Johnson | - | Herself 1 episode, 2003 |
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| Lesley Joseph | - | Herself 1 episode, 2003 |
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| Hilary Kingsley | - | Herself 1 episode, 2003 |
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 | Joe Pasquale | - | Himself 1 episode, 2003 |
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| Jon Peake | - | Himself 1 episode, 2003 |
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| Jonathan Powell | - | Himself 1 episode, 2003 |
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| Gaby Roslin | - | Herself 1 episode, 2003 |
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| Paul Ross | - | Himself 1 episode, 2003 |
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| Rick Sky | - | Himself 1 episode, 2003 |
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| Claire Sweeney | - | Herself 1 episode, 2003 |
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| Margherita Taylor | - | Herself 1 episode, 2003 |
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 | Toyah Willcox | - | Herself 1 episode, 2003 |
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| Anna Wing | - | Herself 1 episode, 2003 |
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| Mal Young | - | Himself 1 episode, 2003 |
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 | Michael Higgs | - | Himself 3 episodes, 2004-2010 |
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 | Cliff Parisi | - | Himself 1 episode, 2004 |
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 | Joel Beckett | - | Himself 1 episode, 2005 |
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| Brooke Kinsella | - | Herself 1 episode, 2005 |
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 | Michelle Ryan | - | Herself 2 episodes, 2005-2010 |
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| John Scott | - | Himself 1 episode, 2005 |
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| Jane Slaughter | - | Herself 1 episode, 2005 |
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 | James Alexandrou | - | Himself 2 episodes, 2007 |
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 | Phil Daniels | - | Narrator 3 episodes, 2007-2008 |
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| Lorna Fitzgerald | - | Herself 3 episodes, 2007-2010 |
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| Carol Harrison | - | Herself 1 episode, 2007 |
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 | Alison Pargeter | - | Herself 2 episodes, 2007 |
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 | Wendy Richard | - | Herself 2 episodes, 2007-2010 |
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 | Kellie Shirley | - | Herself 1 episode, 2007 |
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| David Spinx | - | Himself 1 episode, 2007 |
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 | Joe Swash | - | Himself 1 episode, 2007 |
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 | Sophie Thompson | - | Herself 2 episodes, 2007-2009 |
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 | Kara Tointon | - | Herself 1 episode, 2007 |
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| Molly Conlin | - | Dotty Cotton / - 1 episode, 2008 |
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 | Frankie Fitzgerald | - | Ashley Cotton / - 1 episode, 2008 |
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 | Alan Ford | - | Narrator 1 episode, 2008 |
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 | Robert Kazinsky | - | Himself 1 episode, 2008 |
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 | Martin Kemp | - | Narrator 2 episodes, 2008-2010 |
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 | Lauren Crace | - | Herself 1 episode, 2009 |
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| Anna Karen | - | Herself 1 episode, 2009 |
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| Patsy Palmer | - | Herself 2 episodes, 2008-2009 |
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 | Danniella Westbrook | - | Herself / - 2 episodes, 2009-2010 |
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 | Tiana Benjamin | - | Herself 1 episode, 2010 |
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 | Don Gilet | - | Himself 1 episode, 2010 |
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| Ricky Groves | - | Himself 1 episode, 2010 |
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 | Neil McDermott | - | Himself 1 episode, 2010 |
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| Belinda Owusu | - | Herself 1 episode, 2010 |
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| Lindsey Coulson | - | Herself 1 episode, 2011 |
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| Tony Discipline | - | Himself 1 episode, 2011 |
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 | David Essex | - | Himself 1 episode, 2011 |
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| Devon Higgs | - | Himself 2 episodes, 2008-2011 |
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| Jacqueline Jossa | - | Herself 1 episode, 2011 |
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 | Matt Lapinskas | - | Himself 1 episode, 2011 |
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| Zöe Lucker | - | Herself 1 episode, 2011 |
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| Shona McGarty | - | Herself 1 episode, 2011 |
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 | Steve John Shepherd | - | Himself 1 episode, 2011 |
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| Maisie Smith | - | Herself 2 episodes, 2008-2011 |
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| Jamie Borthwick | - | Himself 2 episodes, 2009-2012 |
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| Matt Evans | - | Himself 1 episode, 2012 |
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| Cheryl Fergison | - | Herself 1 episode, 2012 |
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 | Ricky Grover | - | Himself 1 episode, 2012 |
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| Linda Henry | - | Herself 2 episodes, 2007-2012 |
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